Incorporating epigenetic mechanisms to advance fetal programming theories
نویسندگان
چکیده
منابع مشابه
Fetal programming and epigenetic mechanisms in arterial hypertension.
PURPOSE OF REVIEW To provide an overview of available evidence of the potential role of epigenetics in the pathogenesis of hypertension and vascular dysfunction. RECENT FINDINGS Arterial hypertension is a highly heritable condition. Surprisingly, however, genetic variants only explain a tiny fraction of the phenotypic variation and the term 'missing heritability' has been coined to describe t...
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Epigenetics generates a considerable interest in the field of research on complex traits, including obesity and diabetes. Recently, we reported a number of epipolymorphisms in the placental leptin and adiponectin genes associated with maternal hyperglycemia during pregnancy. Our results suggest that DNA methylation could partly explain the link between early exposure to a detrimental fetal envi...
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Insults during the fetal period predispose the offspring to systemic cardiovascular disease, but little is known about the pulmonary circulation and the underlying mechanisms. Maternal undernutrition during pregnancy may represent a model to investigate underlying mechanisms, because it is associated with systemic vascular dysfunction in the offspring in animals and humans. In rats, restrictive...
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Remarkable progress in the field of epigenetics has turned academic, medical and public attention to the potential applications of these new advances in medicine and various fields of biomedical research. The result is a broader appreciation of epigenetic phenomena in the a etiology of common human diseases, most notably cancer. These advances also represent an exciting opportunity to incorpora...
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THE PHYSIOLOGY OF FETAL PROGRAMMING is a quickly maturing science. Whereas initial studies established and expanded our perception of the phenomenon, more recent studies have begun to focus on the molecular and cellular mechanisms underlying the physiological changes considered to be programming. The reader who is unfamiliar with fetal programming is directed to an ever-expanding body of excell...
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ژورنال
عنوان ژورنال: Development and Psychopathology
سال: 2018
ISSN: 0954-5794,1469-2198
DOI: 10.1017/s0954579418000469